K-PAX MitoNutrient Activator

Multi-Nutrient Nutritional Supplement for Mitochondrial Health*

All cells, with the exception of red blood cells, contain mitochondria, organelles that produce adenosine triphosphate (ATP), the cellular “energy currency”, from adenosine diphosphate (ADP). In addition, mitochondria are involved in many other processes within the body such as cell signaling and regulation of cellular metabolism. Mitochondrial energy metabolism is a critical part of cellular health and function, and influences overall health.

Optimal mitochondrial function depends on:

• Quenching of free radicals produced during normal electron transport chain (ETC) activity
• Integrity of mitochondrial cell membranes
• The transport of critical metabolites, such as fatty acids, into the mitochondria

The Added Support of the “Activator”

K-PAX MitoNutrient Activator is designed to be taken in combination with K-PAX MitoNutrients in those patient populations that require additional energy support.* A differentiating feature is the addition of caffeine along with B-complex vitamins, tyrosine and taurine. Developed by Dr. Kaiser, through diligent trial and error, he found that some patients did not experience the expected results when taking the mitochondrial nutrients alone, but responded well with the addition of low-dose caffeine. The low-dose caffeine in K-PAX MitoNutrient Activator is designed to act as a catalyst to the basic mitochondrial support nutrient formula.* Preclinical and mechanistic studies support the inclusion of caffeine, notably because caffeine increases hippocampal mitochondrial respiratory rates and may induce mitochondrial biogenesis*.1, 2

Individuals requiring additional support may add 1-2 tablets per day of K-PAX MitoNutrient Activator in addition to K-PAX MitoNutrients. Individuals may take this combination until the desired effects are seen, at which time the K-PAX MitoNutrient Activator may be re-evaluated.

About K-PAX

K-PAX MitoNutrients and K-PAX MitoNutrient Activator were formulated by Jon D. Kaiser, MD who has 25 years of experience exploring in immune and mitochondrial health. K-PAX MitoNutrients and K-PAX MitoNutrient Activator are the original formulas which feature a unique micronutrient combination to support mitochondrial health and cellular energy support.* K-PAX MitoNutrients is part of an approach that investigated the impact on occasional fatigue and mental alertness.3

1 Dragicevic N, Delic V, Cao C, et al. Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in …mice and cells. Neuropharmacology. 2012 Dec;63(8):1368–79.

2 Vaughan RA, Garcia-Smith R, Bisoffi M, Trujillo KA, Conn CA. Effects of caffeine on metabolism and mitochondria biogenesis in rhabdomyosarcoma cells compared with 2, 4-Dinitrophenol. Nutrition and Metabolic Insights.

3 Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771–8.