SinusCare

Provides seasonal relief and supports healthy sinus, nasal, lung and respiratory function

• Helps inhibit histamine release
• Eases watery, itchy eyes, sneezing and runny nose
• Supports irritated sinus and nasal passages
• Promotes healthy lung function

Unique Properties
Patient One SinusCare supplies a synergistic combination of micronutrients, bioflavonoids, enzymes, amino acids and herbs that provide multi-faceted support for immune function and respiratory health. This formula provides natural support and quick relief for discomfort associated with immune hypersensitivity and histamine release, including watery, itchy eyes, sneezing, runny nose and nasal congestion.

Key Ingredients
Quercetin, a powerful natural bioflavonoid with strong antioxidant activity, and vitamin C are beneficial for respiratory health. They provide support for stabilizing mast cells that store and release histamine and moderate an exaggerated immune response to allergens. Quercetin inhibits inflammatory enzymes and increases mucus secretion from gastric cells. Vitamin C has been widely studied and is commonly known for its role in moderating the severity or duration of acute immune challenges. This nutrient appears to heighten the immune response to infections, impacting T-cell proliferation. Vitamin C also synergistically improves the ability of quercetin to preserve and increase glutathione levels, reducing oxidative damage. Increasing this potent antioxidant may help reduce nasal obstruction, rhinorrhea and ear fullness.

Bromelain, a proteolytic enzyme purified from pineapple, is a supportive nutrient in helping prevent allergens from crossing the gastrointestinal tract. With the assistance of quercetin and vitamin C, bromelain inhibits the absorption of substances into the body that may induce the allergic response. Bromelain supports normal inflammatory response by hindering the bodys production of kinins and fibrin. This natural enzyme contains constituents that help maintain a healthy cytokine balance. Bromelain has also been found to enhance the absorption of quercetin.

Stinging nettle, an herb named for the fine hairs found along its stems and leaves that break off when touched, has been used as a medicinal plant for centuries. Among other things, nettle roots or leaves were traditionally used for wheezing, shortness of breath, throat inflammations and as an expectorant. Nettles aerial parts may reduce the amount of histamine that is produced in response to an allergen. Stinging nettle leaf has been shown in vitro to inhibit the pro-inflammatory pathways related to allergic rhinitis. Nettle polysaccharides appear to stimulate tumor necrosis factor and T- lymphocyte activity, aiding immune system response.

A derivative of the dietary amino acid l-cysteine, N-Acetyl-l-Cysteine (NAC) has a high affinity for lung tissue, which it supports through mucolytic and antioxidant action. By disrupting disulfide bonds as a result of its sulfur content, NAC naturally thins mucus, which commonly thickens with hyperimmune response. Thinner mucus, along with trapped bacteria and particles, is more easily expelled from the lungs. A precursor to glutathione, supplemental NAC enhances glutathione production and antioxidant protection. NAC is a powerful free radical scavenger and as such supports the bodys natural defense system. Research studies support NACs role in promoting upper respiratory tract and immune system health.

The complementary combination of natural ingredients in SinusCare have been formulated to assist the body in moderating unpleasant immune reactions and support healthy respiration.

Research

• A randomized, double blinded trial of stinging nettle (Urtica dioica) for allergic rhinitis had positive results. It may be... a therapeutic adjunct in sinusitis or... a pivotal therapy in patients with a predominantly allergic Chronic rhinosinusitis
• etiology.
• In a clinical trial, intranasal vitamin C was used for allergic rhinitis. After two weeks, 74 % of subjects treated... exhibited a decrease in nasal secretions, blockage, and edema, compared to 24 % of controls.

References

1. Testa B, Mesolella M, Testa D, Giuliano A, Costa G, Maione F, Iaccarino F. Glutathione in the upper respiratory tract. Ann Otol Rhinol Laryngol. 1995;104:117-9.
2. Helms S, Miller A. Natural treatment of chronic rhinosinusitis Alt Med Rev. 2006;11(3):196-207.
3. Yarnell, Eric. Stinging Nettle: A Modern View of an Ancient Healing Plant. Alternative and Complementary Therapies, June 1998, pp. 180-186.
4. Roschek B Jr, Fink RC, McMichael M, Alberte RS. Nettle extract (Utica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytother Res. 2009;23:920-6.
5. Johnston CS, Meyer CG, Srilakshmi JC. Vitamin C elevates red blood cell glutathione in healthy adults. Am J Clin Nutr. 1993;58:103-5.
6. Bombardelli, E. and P. Morazzoni. Urtica dioica L. Fitoterapia, 1997, Vol.48 (5), pp. 387-402.
7. Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999 Sep;3(9):756-61.
8. NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin C. http://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional
9. Linus Pauling Institute. Vitamin C. http://lpi. oregonstate.edu/infocenter/vitamins/vitaminC/.
10. Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem. 1996;25:189-213. [PMID: 8821975]
11. Ziment I. Acetylcysteine: a drug that is much more than a mucokinetic. Biomed Pharmacother. 1988;42(8):513-9.
12. Kelly GS. Clinical applications of N-acetylcysteine. Altern Med Rev. 1998 Apr;3(2):114-27.
13. Blumenthal M. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council; 2000.
14. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001 Aug;58(9):1234-45.
15. Lakhanpal, P, Rai DK. Quercetin: A Versatile Flavonoid. IJMU. 2007 Jul- Dec;2(2):22-37.
16. Middleton E Jr, Drzewiecki G, Krishnarao D. Quercetin: an inhibitor of antigen- induced human basophil histamine release. J Immunol. 1981 Aug;127(2):546- 50.