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5-HTP is a metabolite of tryptophan and precursor of serotonin and melatonin. Tryptophan - 5-HTP - Serotonin -Melatonin. 5-HTP plays a role in mood, sleep, anxiety, aggression, appetite, body temperature, sexual behavior, and pain sensation. Our 5-HTP is combined with vitamin B-6 as active P5P, an important cofactor in serotonin metabolism. Use with care when combining with SSRIs.*