Dim-Pro Plus nutritionally supports the activity of enzymes that metabolize estrogen and aspirin. Current research demonstrates that BioResponse diindolylmethane increases levels of good estrogens (2-hydroxyestrogens/2-OHE1) which tend to inhibit abnormal cell replication while reducing levels of “bad” estrogens (16-a-hydroxyestrone/16-a-OHE1).
There are three forms of naturally occurring estrogen compounds made in the body – estradiol, estrone, and estriol.
There are also xenoestrogens; synthetic estrogen-like compounds that enter the body through the ingestion and/or inhalation of pesticides, drugs (hormone replacement therapy), fuels, and plastics. Combined, these estrogens represent the body’s systemic estrogen pool.
Estrogen, whether synthetically derived or naturally formed, is broken down through detoxification pathways in the liver and eliminated from the body. This is a crucial step in estrogen metabolism as excessive exposure to circulating estrogens in the blood can trigger aberrant cell growth and function.
There are two different detoxification pathways in the liver by which estrogen can be metabolized. One pathway yields estrogen derivatives known as 2 -hydroxyestrone. The other pathway yields a 16-hydroxyestrone derivative.
The 16-hydroxyestrones have been associated with breast and uterine cancers, cervical dysplasia, uterine fibroids, PMS, endometriosis, and obesity. These conditions are often the result of estrogen over-stimulation or dominance in the body.
DIM works by positively influencing the production of 2-hydroxyestrone metabolites. As DIM increases these good estrogen metabolites, there is a simultaneous reduction in the levels of the 16 -hydroxyestrone form. This shift in estrogen metabolism, evidenced by an increase in the 2:16 hydroxyestrone ratio, reduces the undue influence of the 16-hydroxyestrone metabolites on cell growth and function.