- Large doses of niacin, an essential B-vitamin, have mild sedative effects in animals.
- Hexaniacinate is a slowly-hydrolyzing inositol ester of niacin which offers the nutritional benefits of niacin without the flushing of high-dosage niacin.
- Niacin, especially in combination with chromium, can have a salutary effect on both lipid and carbohydrate metabolism.
- Chromium facilitates the action of insulin, which in turn is needed for the normal control of blood sugar and blood lipids.
- Experimental and clinical studies suggest that niacin has a favorable influence on the metabolism of tryptophan, reducing catabolism in the liver and allowing more to enter the brain, where it can serve as a neurotransmitter precursor.